Ocuphire Pharma Results Presentation Deck

RM 15 Secondary Endpoint: Mean Pupil Diameter Over Time Nyxol Treatment Significantly Reduced PD Starting at 1 Hour Post-Dose through 6 Hours Mean Pupil Diameter (mm) 9 00 CO 3 Mydriatic -1 I ± Max pupil dilation, Treatment 0 F 0.5 p<0.0001 1 MIRA-2 Phase 3 Trial Study Eye, mITT Population p<0.0001 T p<0.0001 I p<0.0001 -Nyxol n=94 3 I p<0.0001 1.5 2 4 Time Post-Treatment with Nyxol/Placebo (Hours) Placebo n=91 Source: MIRA-2 TLR table # 14.2.2.1 (mITT). Standard Error bars are shown. Data includes all three mydriatics (Phenylephrine, Tropicamide, Paremyd) H p<0.0001 6 Ocuphire PHARMA

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