Equillium Results Presentation Deck

Change in UPCR and Best Clinical Response by Subject Legend Complete Response: > 50% UPCR reduction and < 0.5 g/g Complete Response: > 50% UPCR reduction and 0.5-0.7 g/g Partial Response: > 50% reduction UPCR No Response: < 50% reduction or worsening UPCR Maximum Reduction in UPCR (%) equillium 100 90 80 70 60 50 40 30 20 10 0 -10 -20 -30 -40 -50 -60 -70 -80 -90 -100 Sub.1 2.2 g/g Sub.13 Sub.7 1.4 g/g 4.5 g/g Sub.8 0.9 g/g Sub.3 4.6 g/g * Sub.12 6.8 g/g 67% overall response rate Sub.2. 0.9 g/g * Sub.11 0.1 g/g Sub.4 0.5 g/g N = 12 (subjects with > 1 dose and at least 1 post-baseline assessment) * Subjects still actively dosing Subject number with lowest UPCR achieved to date through study completion (week 36) Sub.2 0.6 g/g Sub.5 0.6 g/g Sub.6 0.2 g/g Based on interim data from 2 Sep 2022-subject to change. Abbreviations: ORR-overall response rate= complete and partial response: UPCR urine protein creatinine ratio 28

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