Conference Presentation

Massive, established market Capture market share through disruptive technology We Compete in Industries Ripe for Disruption 22nd Century's core competencies in plant-based research provides solutions across highly-regulated end markets Tobacco Industry Category Attributes Hemp/Cannabis Industry 20+ years of deep, established R&D technologies First and only combustible tobacco product anticipating MRTP approval $817B Market (2018)¹ Demonstrated Strength Commercial Launch Plant-Based Highly-Regulated Consumer-Facing Licensing Opportunities R&D Innovation $85B+ Market (2024E)² 1) Foundation for a Smoke Free World; https://www.smokefreeworld.org/wp-content/uploads/2019/08/FSFW Global-Trends-in-Nicotine 6.22.2020.pdf 2) PR Newswire; https://www.prnewswire.com/news-releases/global-cannabis-market-now-projected-to-exceed-89-billion-by-2024-300904306.html Emerging Presence Ž Commercial Whitespace 22nd Century Group, Inc. Nascent, fast-growing market Highly fragmented industry Opportunity to seize leadership through a differentiated product offering Category entry through impactful partnerships 22ND CENTURY HAS FIRST MOVER ADVANTAGE IN VERY LOW NICOTINE TOBACCO TECHNOLOGY AND ITS FAMILY OF PATENTS IN PLANT-BASED BIOTECHNOLOGY APPLICATIONS ENABLES ENTRY INTO ADJACENT MARKETS 7

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