BenevolentAI Investor Conference Presentation Deck

DEMO Disease Exploration Mechanisms There are 869 Mechanisms related to amyotrophic lateral sclerosis Recommended entities are listed in ascending order of Rank by default. Cluster mechanisms Mechanism name RNA localization to nucleus Filter by: + Related tissues: All Diseases related to amyotrophic lateral sclerosis Rating O ↓ 100% V Data relevance score → Entity Explorer • 0.99 ALS Demo Disease program: ALS demo Data release: 1-42 (latest) Number of entities: 3 Number of unique benchmark genes: 853 530 155 234 amyotrophic lateral sclerosis Disease + Add new entity astrocyte activation Mechanism (GeneOntology) 198 Explore Visualise cellular response to oxidative stress Mechanism (GeneOntology) Related cell: All v Number of benchmark genes Save amyotrophic lateral sclerosis N Disease 245 Saved Shortlists Venn diagram Upset diagram Display geneset genes i Mechanisms Mechanism ontology: All Number of geneset genes amyotrophic lateral sclerosis 530 genes Diseases 51 There are 869 Mechanisms related to amyotrophic lateral sclerosis astrocyte activation 155 genes Benchmark gene overlap related to amyotrophic lateral sclerosis Genetic Evidence: All cellular response to oxidative stress. 234 genes Genetic evidence No Related cell: All Entity definition Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized degeneration of motor neurons in the primary motor cortex, corticospinal tracts, br Benchmark Genes Geneset Genes There are 530 benchmark genes in your selection: SLC18A3, LGALS4, MFN2, LHX3, SYNCRIP, LANCL1, KPNB1, SNCG, CLP1, MADD, S ZNF512B. SNCA, TSPO, SODI. SARMI Show all 530 benchmark genes + Add as new custom list (530) Number of benchmark genes Ⓒ 198 Mechanism ontology. All Number of geneset genes → 245 V Genetic Evidence: All V Benchmark gene overlap 51 Genetic evidence O No Benevolent 7

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