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Limited Use of Data and Lack of Patient Engagement Constrains Productivity ¹ IND = Investigational New Drug Application. fdareview.org, "The Drug Development and Approval Process" (2020). 2 Probability of success for a drug to be approved is estimated to be <12%. 3 PhRMA, "Biopharmaceutical Research & Development: The Process Behind New Medicines" (2015). Drug Development is Inefficient 7 years average time-to-IND¹ $2.6B average cost of drug development³ ~90% failure rate ², 3 23and Me Confidential and Proprietary Information 21

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