Ginkgo Results Presentation Deck slide image

Ginkgo Results Presentation Deck

New partnership with Aldevron has potential to generate substantial near-term royalties mRNA Supply Chain is Expanding for Moderna and Pfizer/BioNTech have paved the way future mRNA therapeutic growth Modality yields faster time to market and strong performance Pfizer + Moderna are expected to produce 4-6 billion doses annually for COVID-19 ● ● Large pipeline of population-scale mRNA vaccines in development (e.g. COVID boosters, flu) mRNA supply chain requires investment Prior to COVID, mRNA modality was experimental and generally being directed to relatively rare diseases Several key components (pDNA, processing enzymes, even freezers, etc.) have become bottlenecked ● Aldevron collaboration dramatically improves availability and cost of Vaccinia Capping Enzyme (VCE), enabling it to be used in support of more therapies and doses New COVID Vaccines Need Absurd Amounts of Material and Labor SCIENTIFIC AMERICAN MEDICINE Companies are scrambling to obtain supplies for hundreds of millions of doses of a type of vaccine that has never been made at this scale before By Charles Schmidt on January 4, 2021 Partner (signed 2021) Program Goals CASE STUDY 2 aldevron Progress to Date Collaboration in Brief Aldevron, a leading manufacturer of nucleic acids and proteins, serving the biotechnology industry. Recently announced pending acquisition by Danaher for $9.5Bn. Engineer organism and create new manufacturing process to improve production volumes and cost of Vaccinia Capping Enzyme (VCE), a key reagent for certain mRNA vaccines Completed program and yielded >10x improvement in process, Aldevron is in the market with novel product H1 UPDATE | AUGUST 2021 GINKGO BIOWORKS 19
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