2022 Highlights and ESG Progress

Our global businesses continue to drive in-market and Group profitable growth and value CIB: leaders in LatAm and strengthening common value proposition in Europe and the US WM&I: Top 3 Best Global Private Banking and preferred asset manager and insurance provider in LatAm and Europe Our global reach with local expertise generates additional business / revenue opportunities... Cross-border & collaboration revenue ...and supports higher and more predictable growth than peers... ...with better efficiency YoY changes +32% Revenue +11% €3.4bn +33% YoY 47% of CIB total revenue Efficiency ratio SAN 39% and profitability levels Peers 61% Private Banking €51bn +2% YoY cross-border & collaboration AuMs 21% of total PB AuMs peers +34% YoY changes in constant euros +23% PBT +13% peers +24% +13% +1% - 0% -4% PB Revenue AM Revenue Insurance GWPs PBT/RWAS Efficiency ratio¹ PBT/AuMs¹ 3.7% SAN 45% 0.29% 2.4% Peers 69% 0.15% Santander Note: Santander data - FY'22. Peer data - 9M'22 or latest available. Peer group corresponds to the those included in the benchmarking exercise for the variable renumeration calculations for these businesses. (1) Includes Private Banking and Asset Management. 10

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