Santander Financial Performance

YoY increase in NII supported by higher volumes and the first impacts of rises in interest rates Net interest income (Constant € mn)1 Yields and Costs (%) () 824 738 751 782 782 10.03% 10.08% 10.23% 10.47% Yield on loans 11.07% 1.87% 2.03% 2.21% 2.39% Cost of deposits 2.58% Q2'21 Q3'21 Q4'21 Q1'22 Q2'22 Q2'21 Q3'21 Q4'21 Q1'22 Q2'22 NII/Average Total Assets 3.62% 3.84% Official interest rate (TIIE)² 4.30% 4.64% Differential 3.79% 3.81% 3.94% 8.2pp 8.1pp 8.Opp 8.1pp 8.5pp 5.19% 6.03% 7.07% Santander (1) Average exchange rate as at 6M'22. (2) Quarterly average. 14

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