Investor Presentation Full Year 2021

108 Investor presentation Full year 2021 Insulin market size and volume market share in Rest of World Insulin market share and market size (DKK billion) Total 57% Fast- 40% 5 acting Long- acting 62% 2 Premix 81% 2 Human 65% 2 Novo Nordisk Competitors Market growth A Market share 80% 11 +1.2% +1.1% 60% 4.9% +1.6% Insulin volume: market share Rest of World 20% 57% 15% 40% 10% -1.2% +1.1% 20% 5% 0% +1.4% 3% 0% 0% Nov Nov -2.1% +1.6% 2018 -NN market share 2021 Market growth (right axis) NN growth (right axis) Source: IQVIA, Nov 2021; LHS graph - Value, RHS Graph - Volume, MAT; Share of growth not depicted due to too high numbers; NN: Novo Nordisk

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