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Investor Presentaiton

BIOND BIOLOGICS INspire: Intracellular delivery of anti-HPV-E7 (In-vitro PoC #2) HPV-E7 is an oncoprotein that activates cell cycle (and cell proliferation). Intracellular delivery of an anti-HPV- E7 protein agent led to cell cycle arrest and killing of HPV18-E7+ cervical cancer cells 100 Positive Control (CDK 4/6 Inhibitor) E2 integrated HPV E2 Genomic DNA E7- E7 + Gene Transcription E2F transcription factor (Rb-bound) Rb E2F (unbound) E7 Rb DNA cell cycle activation; proliferation Antibody Payload Anti-E7 Carrier Cell Cycle Arrest (%) EN WB 2 g 70 Chemical Modifications 0 60 88 80 Anti-E7-Carrier Negative Controls 100 120 140 160 Time (hr) Biond Biologics Corporate Presentation | May 2021 | Non-confidential 涯 37
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