Investor Presentaiton
BIOND
BIOLOGICS
INspire: Intracellular delivery of anti-HPV-E7
(In-vitro PoC #2)
HPV-E7 is an oncoprotein that activates cell cycle (and cell proliferation). Intracellular delivery of an anti-HPV-
E7 protein agent led to cell cycle arrest and killing of HPV18-E7+ cervical cancer cells
100
Positive Control
(CDK 4/6 Inhibitor)
E2
integrated HPV
E2
Genomic DNA
E7-
E7 +
Gene
Transcription
E2F transcription
factor (Rb-bound)
Rb
E2F
(unbound)
E7 Rb
DNA
cell cycle activation;
proliferation
Antibody
Payload
Anti-E7
Carrier
Cell Cycle Arrest (%)
EN WB 2 g
70
Chemical
Modifications
0
60
88
80
Anti-E7-Carrier
Negative
Controls
100
120
140
160
Time (hr)
Biond Biologics Corporate Presentation | May 2021 | Non-confidential
涯
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