Investor Presentaiton
INOVIO's Technology Delivering Precisely Designed
Plasmids with Proprietary Smart Devices
INOVIO's DNA medicine powers a patient's immune system
to generate functional antibodies and killer T cells.
Colls
Syringe
Electrical
pulses
DNA
vaccine
Cell membrane
Temporary
openings
Nucleus
DNA
vaccine
Syringe inserted into selected muscle
or skin tissue injects the DNA vaccine.
Controlled, milli-second electrical pulses
are applied to the needle electrodes.
which then form an electric field.
The electrical field creates temporary
openings in the cell membrane, allowing
significantly greater amounts of the
DNA vaccine to enter cells.
Lymph node
Immune
cells
Antigen-
presenting
cell
Antibodies
Killer T cells
Lymph node
44
In the lymph node, the interaction of
antigen-presenting cells and other
immune cells results in antibodies that
can prevent future infections or killer
T-cells that can clear already-infected
cells.
Antigen-presenting cells engulf the
antigens and carry them to lymph nodes.
The cell membrane reseals and the
trapped DNA causes the cell to produce
the antigen coded by the DNA.
Inovio Pharmaceuticals, Inc, 2010. All Rights Reserved.
INOVIO
POWERING DNA MEDICINESView entire presentation