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Reimagining Medicine

Company overview Financial review 2023 priorities Appendix GROWTH Cosentyx® Q4 sales impacted mainly by a revenue deduction true-up related to prior quarters in the US and China COVID lockdowns Sales evolution USD m, % cc Ex-US US -9% / -2%1 +5% 1,243 4,718 4,788 1,080 473 1,835 2,018 447 *Cosentyx® Q4 performance US: -18%-6%. Impacted by a RD true-up relating to prior quarters in 2022 driven primarily by a higher Medicaid channel mix Ex-US: +5% (cc), growth driven by core indications China: Impacted by COVID and stock compensation provision for 2023 NRDL re-listing Volume continues to grow across key geographies FY sales USD 4.8bn (+5% cc) driven by ex-US (+20% cc) Future growth mainly driven by LCM 770 2,883 2,770 633 2021 2022 Q4 2021 2022 2023: Expect sales broadly in line with PY (H2 growth and H1 decline²) 2024+: LCM anticipated to drive next phase of growth FY LCM-life cycle management. RD - revenue deduction. NRDL - national reimbursement drug list. 1. US CosentyxⓇ sales growth was impacted by a revenue deduction true-up, which was related to prior quarters in 2022. Global sales declined -9% in Q4 vs. PY (decline would have been -2% without the true-up). US sales declined -18% in Q4 vs. PY (decline would have been -6% without the true-up). 2. Expect continued RD dynamics in US. 24 Investor Relations | Q4 2022 Results ✓ NOVARTIS | Reimagining Medicine
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