Investor Presentation First Nine Months of 2022 slide image

Investor Presentation First Nine Months of 2022

61 Investor presentation First nine months of 2022 Novo NordiskⓇ Large opportunity for activating more people with obesity to seek treatment and increasing the number of prescribers ONCE-WEEKLY wegovy® semaglutide injection 2.4 mg 75% WegovyⓇ patient characteristics in the US 38% 81% 38.8 of patients new to anti- obesity medication¹ of patients are female Average BMI of patients have ≥3 co- morbidities Of the people with overweight or obesity in the US, almost 90% have a weight-related comorbidity BMI 140 (million of people) 27-30 30-35 35-40 (43) (52) ≥40 (25) (20) Total (140) No obesity-related comorbidity² 7 6 2 2 17 million people with a BMI > 27 Any obesity-related comorbidity Hereof metabolic syndrome³ 36 46 23 18 123 21 26 14 12 72 1 Patients new to anti-obesity medication reflect source of business, where 75% of patients starting WegovyⓇ are naïve to anti-obesity medication treatment and 25% have either switched from or restarted anti-obesity treatment, IQVIA Feb. 2022; 2 Individuals without any of the following obesity related conditions: T2DM, Pre-diabetes, NASH, NAFLD, obstructive sleep apnea, osteoarthritis, PCOS, ASCVD, Heart failure, asthma, urinary incontinence, hypertension, chronic kidney disease stg. 3 or 4, musculoskeletal pain, dyslipideamia, metabolic syndrome; 3 Metabolic syndrome defined as two or more of dyslipidaemia; hypertension; prediabetes OR type II diabetes Source: Novo Nordisk real world research; National Health And Examination Survey (NHANES) cycles 2015-2016 and 2017-2018
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