Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results slide image

Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results

Our Unique Biopharma Model is Delivering on Our Third Phase of Growth and Evolution Our Strategy: Maximizing Key Growth Drivers While Expanding Pipeline for Sustainable Growth $1.30B(1) $297M(2) $7M(3) Net Sales (1) Net sales for year ended Dec. 31, 2019. (2) Net sales for year ended Dec. 31, 2014. (3) Net sales for year ended Dec. 31, 2011. HORIZON 2011-2013 2019+ Expanding Pipeline and Therapeutic Area Focus Maximizing KRYSTEXXA opportunity • • Reinvesting cash flow into TEPEZZA launch and growth • . Building pipeline and presence in core therapeutic areas 11 medicines; 7 for rare diseases Rare Disease Focus Reinvested cash flow into acquiring rare disease portfolio Invested in repositioning and rejuvenating KRYSTEXXA • Built out R&D capabilities 2014-2019 • Formation • Created sustainable, cash-flow positive company via initial portfolio • Built out commercial capabilities . IPO in 2011 with 2 medicines 6
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