PitchSend

Investor Presentaiton

Rigosertib Interferes with Multiple Signaling Pathways 4 Plk1 inhibitor ATP-binding pocket RGS PLK1 1 Rigosertib (ON-01910.Na) RGS 5 PI3K-Akt inhibitor 2 PI3K RAS/RAF pathway inhibitor Akt RAS RGS RAF 3 6 Microtubule-destabilizing agent sistance genes RGS 00 Sensitivity genes Free */ẞ-tubulin Microtubule JNK-mediated activator K-RAS SosGEF RGS Mitotic stress MEK B-RAF P ROS C-RAF Figure adapted from Monfort-Vengut, Pharmaceutics, 2023 1: Reddy, J. Med. Chemistry, 2011 2: Athuluri-Divakar, Cell, 2016 3: Ritt, Mol. Cell, 2016 4: Atanasova, Clin. Cancer Res., 2019 5: Anderson, Mol. Cancer Ther., 2013 6: Jost, Mol. Cell, 2017 I ERK I Proliferation ↓ JNK ONCONOVA THERAPEUTICS

View entire presentation