Q2 2021 Results - Reimagining Medicine slide image

Q2 2021 Results - Reimagining Medicine

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix References For Oncology, 2021 is a breakthrough year of delivering transformative innovation Readouts 177Lu-PSMA-617 Ph3 - mCRPC Submissions JAKAVI ruxolitinib Iptacopan Ph2 - PNH Canakinumab Ph3 NSCLC 2L TABRECTA (capmatinib) tablets Asciminib Alpelisib Ph3 - PROS KYMRIAH™ (tisagenlecleucel) Ph2 - FL KYMRIAH™ (tisagenlecleucel) Ph3 GEP NET (OS) LUTATHERA Designations EU, JP in a/c GVHD Asciminib FDA BTD in 3L CML EU in NSCLC Sabatolimab FDA Fast Track in MDS US, EU in CML 3L Alpelisib 177Lu-PSMA-617 EU Orphan designation in PROS FDA BTD in mCRPC 177Lu-PSMA-617 US, EU in mCRPC KYMRIAH™ (tisagenlecleucel); Spenden for infusan Canakinumab US, EU and JP in FL US in aNHL 2L Canakinumab Ph3 NSCLC 1L US in NSCLC 1L1 KYMRIAH™ (tisagenlecleucel) fr Ph2aNHL 2L S Tislelizumab US in 2L ESCC KISQALI ribociclib Ph3 - HR+ HER2- ABC (M-2 OS) Tislelizumab US in NSCLC Alpelisib US in PROS 1. Depending on timing of final read-out submission may move to early 2022 31 Investor Relations | Q2 2021 Results ✓ Achieved Readout not supportive 1 NOVARTIS | Reimagining Medicine
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