American Thoracic Society - Sanofi Investor Call

Patient-Reported Outcomes: St. George's Respiratory Questionnaire SGRQ Total Score LS mean change ± 95% CI 0 -2 + T T -8 -10 -12 Placebo Dupilumab -14 T T 0 4 12 24 36 52 Week 461 439 Dupilumab 461 444 No. of participants with observed change from baseline Placebo 407 434 430 436 ATS 2023 Week 52 LS mean difference (95% CI) -3.4 (-5.5 to -1.3) P=0.002 414 400 407 415 Lower score indicates a better quality of life 28

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