EVOLUTION AT MERCK - INVENTING FOR LIFE

GROWING GLOBAL DEMAND FOR VACCINES PROVIDES SUSTAINABLE MARKET OPPORTUNITY MERCK INVENTING FOR LIFE Growth over the next decade driven by: • Increasing Coverage: Driving penetration of inline products in high income markets (U.S./EU) • Globalization: Expanding markets and increasing penetration for inline and future pipeline products • Innovation: Launching pipeline products Global vaccine sales ($B)¹ $35 +6% $40 - $45 $55 - $65 1Source: Evaluate Pharma, IMS, Company reports, DCVM projections # 2018 2023 2028 Mike Nally | 63

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