Investor Presentation Full Year 2021

127 Investor presentation Full year 2021 Operating profit expected to be positively impacted by currencies in 2022, partly countered by net financials Avg. 2021 vs. 2020 Exp. Avg FY 2022 vs. FY 2021¹ 10% 6% 2% Hedged -2% -6% -10% USD/DKK CNY/DKK JPY/DKK CAD/DKK GBP/DKK 5% -10% Non- hedged -25% -40% RUB/DKK INR/DKK ARS/DKK BRL/DKK TRY/DKK 1 Year-to-date realised data and remainder expected flat currency development based on the spot rate as of 28 January 2022 . Novo NordiskⓇ FY 2021 Negative impact on operating profit of DKK 2.3 billion Foreign exchange net gain of DKK 0.3 billion FY 2022 outlook Estimated positive impact on operating profit around 7%- points • Estimated loss of around DKK 2.8 billion on net financials: Mainly related to the US dollar Reflecting a higher estimated avg. US dollar in 2022 vs. FY2021 Hedging costs

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