Investor Presentaiton

Methylation is a key determinant of the epigenomic state INVESTOR 20 DAY 23 Epigenomic state Gene Unmethylated Gene A may be functionally active controls how our cells Blood cell function ON Methylated Gene A is silenced Liver cell Single Genome Genome 10,000s of epigenomic switches OFF Variable methylation state Blood cell 0 0 1 0 1 0 1 0 1 Liver cell 0 1 1 0 0 0 1 0 1 ... 100s of cell types Liver cancer cell 0 1 1 0 1 1 1 1 GUARDANT Unique fingerprint of disease 27

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