BenevolentAl Therapeutics Pipeline and Triage

Data Preparation: Optimising the set-up 1. Data Preparation 2. Target Prediction 3. Target Triage 4. Target Validation {!!! Focus and curate a biological question Graph Completion Human Queries 1 2 3 4 MM Reinforcement Learning 'omics Target Safety Drugs? Metadata Score Tgt1 Safe Partial OPC, GCNN 0.71 Tgt2 Unsafe No SQT 0.65 Tgt3 Safe Yes OPC, CROM 0.51 Tgt4 PhaseII Offtgts OPC 0.49 ☐ ☐ ☐ ☐ Model fleet predictions Prediction evaluation Equip experts with data Triage predictions Perform Assays Analysis & retro 1. Disease Data Package 2. Predictions Package 3. Hypothesis Package 4. Validated Hypothesis Package Al Benevolent 15

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