Q4 2021 Results slide image

Q4 2021 Results

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix CosentyxⓇ maintains strong market position; progressing LCM Sales evolution USD m, % cc Ex-US Cosentyx E AZ K K L US FY 4.0bn +13% FY 4.7bn +17% 1,247 1,243 ■ Maintaining strong growth and market position ■ Demand driven across indications in US, Europe, China Expanding clinical differentiation Hidradenitis suppurativa Ph3 positive 1,175 1,109 1,012 1,053 ◉ Approved for JPSA and ERA in the US 930 944 494 473 460 ■ 423 372 408 354 330 576 614 640 686 715 753 770 645 Approval for PSO flexible dosing in EU ■ GCA Ph2b positive; Ph3 ongoing ☐ Anticipate 10+ indications overall Expect double-digit growth in 2022 Expect historical Q1 sales pattern Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 2020 2021 SpA Spondyloarthritis JPSA - Juvenile psoriatic arthritis ERA - Enthesitis related arthritis PSO-Psoriasis GCA Giant cell arteritis LN- Lupus nephritis LP-Lichen planus 26 Investor Relations | Q4 2021 Results ✓ NOVARTIS | Reimagining Medicine
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