Avantor Results Presentation Deck

Q4 and FY adjusted P&L USD in millions Reported Revenue Core organic growth Adj. Gross Profit Adj. Gross Profit % Adj. EBITDA Adj. EBITDA % Adj. Earnings Per Share Free Cash Flow Adj. Net Leverage Navantor™ Q4 2022 $1,795.0 2.7% $615.1 34.3% $359.5 20.0% $0.32 $172.0 3.7X4 FY 2022 $7,512.4 6.0% $2,617.2 34.8% $1,570.7 20.9% $1.41 $710.2 3.7X4 COMMENTS Q4 core organic growth of 2.7%, net of 170 bps days headwind¹ FY core organic growth of >20% in bioproduction and double digit in AT/AM 1. 2. 3. Conversion: Free cash flow / Adj. Net Income. 4. Represents Adj. Net Leverage as of December 31, 2022. Q4 expansion: ~30 bps, FY expansion: ~90bps Driven by M&A, proprietary growth and commercial excellence Q4 expansion: ~60 bps, FY expansion: ~110 bps Gross profit performance and productivity offset inflation and investments Q4 & FY Adj. EPS ahead of updated guidance Double digit adj. net income growth in 2022, excluding FX² Growth investments for multi-year contracts and working capital FCF conversion of -75% in FY 2022³ FY deleveraging of 0.5X Within target leverage of 2X - 4X Note: Core organic growth is organic growth net of COVID-19 impact. Normalizing for differences in number of selling days between comparable periods. Represents foreign exchange translation exposure, primarily from European business (~35% of sales). 4

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