EVOLUTION AT MERCK - INVENTING FOR LIFE slide image

EVOLUTION AT MERCK - INVENTING FOR LIFE

ADDRESSING TUMOR TYPES WITH HIGHEST INCIDENCE, INCLUDING BREAST AND PROSTATE Breast cancer market expected to grow to $38B by 20281 ⚫ TNBC represents 10-15% and ER+/HER2- represents ~65% of all breast cancers • Program addresses different stages of disease and lines of therapy Prostate cancer market expected to grow to $15B by 20281 mCRPC represents 20% and mHSPC represents 20% of all prostate cancers • Broadest I-O development program addressing all stages of mCRPC and moving into mHSPC 1Representative of U.S., EU5, and Japan Source: GLOBOCAN 2018. International Cancer Research Agency 2018 Global incidence of top tumor types Other cancers 7,753,946 (42.9%) Lung 2,093,876 (11.6%) Breast 2,088,849 (11.6%) MERCK INVENTING FOR LIFE Colorectal 1,849,518 (10.2%) Cervical 569,847 (3.2%) Esophageal Liver 572,034 (3.2%) Prostate 1,276,106 (7.1%) Stomach 1,033,701 (5.7%) 841,080 (4.7%) # Mike Nally 61
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