Eleusis SPAC
IV Psilocybin Pharmacokinetics and Pharmacodynamics (PK/PD): Academic Studies
IV administration enabled (1) immediate target drug intensity, and
(2) greatly reduced treatment time and variability compared to oral administration
Psilocin PK following IV and Oral Psilocybin
eleusis
Plasma psilocin concentration
(µg/L)
100-
10-
0.1+
0 60
Oral (0.22 mg/kg)
IV (1mg, bolus)
120 180 240 300 360
Time
Drug effects rated 0-10
(mean values+SEM)
10
9
8
(O
3
2
1
O
-1 0 1 2 3
IV Psilocybin PD
2mg psilo (n = 6)
1.5mg psilo (n = 3)
4
5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Minutes post end of 60 s 10ml injection
Source: 1) Hasler, F. et al. (1997). Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man. Pharmaceutica Acta Helvetiae,
72(3), 175-184.2) Carhart-Harris et al. (2011). The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation
of tolerability. Journal of Psychopharmacology, 25(11), 1562-1567.
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