Kymera Investor Presentation Deck

● ● KT-474 Showed Meaningful Signs of Clinical Activity in AD, Comparing Favorably to Placebo Benchmarks and SOC Encouraging initial EASI score reductions sustained after cessation of dosing Peak pruritus reductions, and responder rates, significantly greater than placebo and SOC benchmarks Investigator Global Assessment (IGA) scores improved in 2 of 7 patients and remained stable in the others AEASI APeak Pruritus NRS Peak Pruritus NRS Responder (week/24hrs) KT-474 Part C Day 28 -37% -52% 57%/71% Day 42 -36% -63% 57%/71% Placebo Benchmarks Week 4 -12 to -25%* -11%¹ 4 to 17%** Dupilumab Phase 3 Week 4 -52%¹ -34%¹ 23 to 40% 1,2 *Range from 7 different Phase 2 and Phase 3 trials; **Range from 10 different Phase 2 and Phase 3 trials; ¹Simpson EL, et al. NEJM 2016;375:2335-2348; 2Bieber T, et al. NEJM 2021;384:1101-1112; The Dupilumab clinical trial was conducted by other parties in a similar patient population with different enrollment criteria from Part 1C of our Phase 1 clinical trial evaluating KT-474. Results do not reflect a head-to-head trial and are shown for illustrative purposes only KYMERA Ⓒ2023 KYMERA THERAPEUTICS, INC. PAGE 24

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