Investor Presentaiton

Investor presentation Full year 2018 Slide 68 GLP-1 effect dependent on level of blood glucose • • . GLP-1 mechanism of action when blood sugar levels increase Increases insulin secretion in the pancreas Reduces glucagon secretion in the liver Slows gastric emptying in the gut Creates sense of satiety in the brain Brain GLP-1 lowers blood glucose in patients with type 2 diabetes Glucose (mmol/L) 18 16 14 12 10 8 Type 2 diabetes patients, no GLP-1 Type 2 diabetes patients, with GLP-1 Healthy controls receiving saline changing diabetes GLP-1 Liver Gut Pancreas 4 6420 Breakfast Lunch Snack 22:00 02:00 06:00 10:00 Time Source: Rachman et al. Diabetologia 1997;40:205-11 14:00 18:00 novo nordisk

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