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Q2 2021 Results - Reimagining Medicine

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix References KisqaliⓇ grew 36% in Q2 with share gains ex-US Sales evolution USD m, % cc Ex-US US Strength of OS data in aBC is driving differentiation in the class Updated OS data from MONALEESA-3 presented at ASCO showed prolonged and consistent OS benefit with a median OS of ~4.5 years1 Only CDK 4/6i to demonstrate OS benefit in 2 Ph3 trials and longest median OS +36% 225 KisqaliⓇ gaining growth momentum despite slow market recovery 159 142 80 79 Q2 2020 Ex-US: Continued strong double-digit growth, with uptake driven by patient share gains in Europe; market leader in pre-menopausal setting in France, Italy and Spain ■ US: Q2 sales +17% vs. Q1, benefitting from higher demand due to increased field force reach coupled with targeted digital engagement Potential to become the only CDK4/6i in intermediate and high-risk eBC NATALEE adjuvant study completed enrollment; readout expected in 2022 83 ■ Q2 2021 aBC advanced breast cancer eBC early breast cancer 1. Intent to treat population. 28 Investor Relations | Q2 2021 Results NOVARTIS | Reimagining Medicine
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