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Investor Presentaiton

Arena Pipeline Overview Pfizer Asset (MoA) / Indication Pre-Clinic Phase 1 Phase 2 Phase 3 Etrasimod (S1P) • Ulcerative Colitis Crohn's Disease Atopic Dermatitis . Alopecia Areata Eosinophilic Esophagitis Other Pipeline and Partnered Assets Ralinepag (IP agonist) / PAH • RIST4721 (CXCR2) / PPP • • Olorinab (CB2) / IBS Pain Temanogrel (5-HT2A) / MO & RP APD418 (B3-AdrR)/Acute HF Beacon Discovery Inflammation & Immunology 1) PAH = Pulmonary arterial hypertension; HF 1 = Discontinued 17 heart failure; PPP = palmoplantar pustulosis; MO = Microvascular obstruction; RP = Raynaud's Phenomenon

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