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Investor Presentaiton

DS-5670 Current development status Development of COVID-19 vaccine progressed FY2021 FY2022 H1 H2 H1 Ph1/2 study Ph1/2/3 booster vaccination Planning Ph3 study in Japan (JP) Dose setting Ph2 Development of initial vaccination = Dose setting Ph2 study ● • Results presented no significant safety concerns. The neutralizing antibody titers 14 days after the 2nd shot of DS-5670 have demonstrated adequate immunity. - Planning to start Ph3 study in Japan in FY2022 H1 Study design . Subjects: COVID-19 unvaccinated Japanese healthy adults • Randomized, non-controlled, parallel- group comparison study (30μg and 60µg) • Investigate safety, immunogenicity (anti- SARS-CoV-2 neutralizing activity of RBD IgG in blood, antibody titer) and PK H2 Daiichi-Sankyo 33
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