Q4 2022 Results

Company overview Innovation: Pipeline overview Cardiovascular Financial review Immunology 2023 priorities Innovation: Clinical trials Neuroscience Clinical Trials Update Includes selected ongoing or recently concluded global trials of Novartis development programs/products which are in confirmatory development or marketed (typically Phase 2b or later). For further information on all Novartis clinical trials, please visit: www.novartisclinicaltrials.com Oncology Appendix Abbreviations Other 59 Investor Relations | Q4 2022 Results NOVARTIS | Reimagining Medicine

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