Fourth Quarter & Full Year 2022 Financial & Business Update

Net Product Sales of $1.7 Billion in 2022; 23% Growth Over 2021 In millions 4Q21 3Q22 4Q22 FY21 FY22 Total Revenues Net product YoY Growth $369 $428 $464 $1,386 $1,707 sales In millions 4Q22 FY22 ADCETRIS $176 $219 $238 $706 $839 $528 +23% +25% $510 $498 PADCEV $93 $105 $122 122 $340 $451 $430 $426 TUKYSA $94 $88 $86 $334 $353 TIVDAK $6 $16 $18 $6 $63 $464 +26% +23% Royalty $46 $44 $53 $151 $432 $428 $165 $369 $383 revenues Collaboration & license $15 $38 $11 $38 $91 agreement revenues 4Q21 1Q22 2Q22 3Q22 4Q22 Total $430 $510 $528 $1,574 $1,962 Net Product Sales ■Royalties ■ Collaboration & License Agreement Revenues revenues Seagen Note: Amounts may not total due to rounding 18

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