Full Year 2023 Investor Presentation

101 Investor presentation Full year 2023 Novo NordiskⓇ MASH patient journey underscores key barriers to overcome for Novo Nordisk to be successful ~22 million people are expected to live with MASH F2-F4c by 2030 Global patients (in millions) 25 20 20 dodo MASH prevalence Hurdles Low disease awareness Inadequate patient No treatment referrals¹ options No prognostic biomarker Few patients receiving diagnosis 15 10 0 5 Prevalence Diagnosed 1 Referrals and identification Access Build strong presence . Create urgency to treat in MASH Build strong speciality-referral process Engage Endos, Hepas and PCPS • Market preparation priorities Increase diagnosis rate Momentum towards NITs in clinical practice and guidelines NITs for diagnosis, screening and monitoring High expected investment level ○ Low expected investment level MASH: Metabolic dysfunction-associated steatohepatitis; Endos: endocrinologist; PCP: primary care physician; NIT: Non-invasive tests; Hepas: hepatologists; F: Fibrosis stage Source: Estes C, Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease, Hepatology, 2018 Evidence generation Build understanding of importance of addressing underlying cause of disease Stop clinical progression amongst physicians and payers

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