Investor Presentaiton

RECONCILIATION OF NON-GAAP FINANCIAL MEASURES The following table presents a reconciliation of total revenue, net interest income, net interest margin and pre-tax margin prepared in accordance with GAAP to such measures on a fully taxable equivalent (FTE) basis, which are non-GAAP financial measures. Management believes this presentation provides a clearer indication of these financial measures for comparative purposes. Reported FTE Adj. FTE $ 1,677.0 $ 1,644.5 4Q21 $ 1,667.0 3Q21 $ 1,633.8 2Q21 $ 1,580.3 $ 10.0 $ 10.7 Revenue 1Q21 $1,583.4 $ 8.3 $ 6.6 4Q20 $ 1,521.9 $ 10.7 $ FY 2021 $ 6,464.5 35.6 FY 2020 $6,100.8 $ 34.4 $1,588.6 $ 1,590.0 $1,532.6 $ 6,500.1 $ 6,135.2 Net Interest Income 4Q21 3Q21 2Q21 1Q21 4Q20 FY 2021 Reported FTE Adj. FTE $ SSS $ 360.6 $ 346.4 $ 335.6 $ 340.1 334.4 $ 1,382.7 $ 10.0 $ 10.7 $ 8.3 $ 6.6 $ 10.7 $ 35.6 370.6 $ 357.1 $ 343.9 $ 346.7 $ 345.1 $ 1,418.3 NIM - Reported 0.96% 0.95% 0.95% 0.98% 1.01% NIM - FTE 0.99% 0.98% 0.97% 1.00% 1.05% Pre-Tax Margin 4Q21 3Q21 4Q20 FY 2021 FY 2020 SSS $ Revenue Reported - Pre-Tax Income - Reported FTE Adj.* Revenue FTE - Pre-Tax Income - FTE $ 1,667.0 $1,633.8 $1,521.9 $ 6,464.5 509.6 $ 518.1 $ 373.4 $ 2,010.1 $ 10.0 $ 10.7 $ $6,100.8 SS $ 1,627.6 10.7 $ 35.6 $ 34.4 $ 1,677.0 $ 1,644.5 $1,532.6 $ 6,500.1 $ 519.6 $ 528.8 $ $ 6,135.2 384.1 $2,045.7 $1,662.0 Pre-Tax Margin - Reported Pre-Tax Margin - FTE 30.6% 31.0% 31.7% 32.2% 24.5% 31.1% 26.7% 25.1% 31.5% 27.1% * FTE Adjustment applies to both revenue and pre-tax income FY 2020 $ 1,443.2 $ 34.4 $1,477.6 northerntrust.com | 2022 Northern Trust 12

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