Investor Presentation Q1 2023

47 Investor presentation First three months of 2023 Insulin market size and volume share of growth and market share Insulin market share and market size (DKK billion) Total 45% Long- Acting 38% Fast- 52% 97 Acting 46 71% Premix 16 32% Human 23 Novo Nordisk 137 Competitors Market growth A Market share 274 3.4% +0.5% 50% 40% 2.9% +1.3% 30% 7.2% -0.3% 20% Insulin volume: Market share 10% -7.5% +1.5% 0% Feb -0.7% -1.9% 2020 -NN market share Source: IQVIA, Feb 2023, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Novo NordiskⓇ 46% 10% 7% 4% -1% 1% -2% -3% -5% Feb 2023 Market growth (right axis) NN growth (right axis)

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