Q1 2023 Earnings Presentation

Q1 2023 YEAR-OVER-YEAR COMPARISON Q1 2023 Non-GAAP Financial Performance [$M, except EPS] Revenues Operating Income Operating Margin (%) EPS Free Cash Flow [$M] Cash, Equivalents & Short-term Investments Net (Debt)/ Cash WC-to-revenue ratio* Q1 2023 $685.3 $139.4 2023 Bruker 20.3% $0.64 $62.5 Mar 31, 2023 $597.9 ($632.8) $0.43 Q1 2022 $595.0 $115.8 19.5% $0.49 $58.8 Dec 31, 2022 $645.5 ($575.4) $0.43 A +15.2% +20.4% +80 bps +30.6% +$3.7 A -7.4% +10.0% flat Comments (year-over-year) Reported revenue growth of +15.2%, despite FX headwind of (4.5%) BRUKER ▪ Organic revenue growth of +17.6%; excellent execution from all groups with gradually improving supply chain Non-GAAP operating margin up +80 bps; solid non-GAAP gross margin expansion and OPEX volume leverage, partially offset by Project Accelerate 2.0 investments ▪ Non-GAAP EPS $0.64, up +30.6%, on strong operating income growth, share buybacks and a lower tax rate *On trailing twelve months revenue. Reconciliations of non-GAAP to GAAP financial measures are available in our earnings press release and at the end of this presentation. ■ Free cash flow up +$3.7M, on improved profitability ▪ Cash and investments down on capital expenditures, acquisitions/investments, and share repurchases Q1 2023 Earnings Presentation | May 4, 2023 I 10

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