Investor Presentaiton

Comprehensive mRNA flu vaccine program SP0273 Days 29 mRNA Flu QIV mRNA Flu QIV Dose 1 mRNA Flu QIV Dose 2 n=65 & 65 n=65 & 65 Adults Adults mRNA Flu QIV Dose 3 n=65 & 65 & 18-64 yo ≥65 yo Fluzone Standard Dose Flublok n=60 & 60 n=60 & 60 Fluzone High-Dose n = 0 & 60 mRNA neuraminidase (NA) Days 29 mRNA NA Dose 1 n=30 & 30 Adults 18-64 yo Adults mRNA NA Dose 2 n=30 & 30 & ≥65 yo mRNA NA Dose 3 n=30 & 30 Fluzone High-Dose n=30 & 30 53 Vaccines Investor Event sanofi Phase 1/2 study Flu QIV (modified mRNA) - Safety and immunogenicity with 3 different LNPs Neuraminidase (unmodified mRNA and LNP #1) - Pilot study to test neuraminidase immunogenicity

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