Investor Presentation Q1 2023

131 Investor presentation First three months of 2023 Insulin market size and volume market share in North America Operations Total Insulin market share and market size (DKK billion) Long- acting 38% 43% 109 Fast- acting 51% ထ 81 59% Premix 8 25% Human 16 Novo Nordisk Competitors NAO Market growth A Market share Insulin volume: Market share 60% 12% 214 5.8% +0.6% 4.8% +1.1% 40% 8% 38% 4% 8.8% +0.1% 20% m 0% -3% -4% -5.2% +1.2% -5% 0% -8% Feb Feb 2020 2023 3.6% -1.5% NN market share -Market growth (right axis) Note: Insulin market numbers do not reflect rebates. Source: IQVIA, Feb 2023, LHS graph - Value, RHS Graph - Volume, MAT, all countries. Share of growth not depicted due to too high numbers; NN: Novo Nordisk -NN growth (right axis)

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