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Immunology Investor Event

The Leading Immunology brand in Specialty Respiratory U.S. monthly respiratory NBRx¹ 3,500 Feb 2020 COVID19 Jan 2022 sanofi DUPIXENT (dupilumab) IgE IL-5s Outstanding performance 34 - - 19% Asthma 12Y+ biologic penetration² 5% Asthma 6-11Y biologic penetration² #1 Asthma NBRX share (28%) QTD Q1'22³ #1 in Asthma new patient share in Germany (31%)4 #1 total Asthma patients share 28% and new patient share 36% in Japan5 Potential best-in-disease Type 2 Asthma profile6 approved 6Y+ in U.S. & EU and 12Y+ in JP 1. IQVIA Custom US Monthly National Source of Business (Asthma, CRSWNP indications), Jan 22. 2. IQVIA Custom Monthly Patient Report, Jan'22 3. IQVIA Custom US Weekly National Source of Business, 2/18/22 4. Germany IQVIA LRX-Database. DupixentⓇ asthma biologics market (naïve and switches) Source of Business, Observational period 01/2022. 5. Japan local ATU W13 Jan '22. 6. Type 2 phenotype: Eos ≥150 or FeNo ≥ 20 ppb, and/or OCS dependence. Leading Immunology Brand in US NBRx. 21 Immunology Investor Event କ First biologic approved in CRSWNP in the U.S., EU, JP and CA
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