Reshaping the HIV treatment and prevention landscape

Integrase inhibitor-based LA pipeline drives future growth Potential options for self administration and ultra long acting Capsid Inhibitor Inhibits formation of HIV capsid which is critical for viral replication Broadly Neutralising Antibodies (N6LS) Blocks HIV replication by attaching to CD4 binding site Maturation Inhibitor Blocks protein processing late in the viral replication cycle Cabotegravir Nucleoside Reverse Transcriptase Translocation Inhibitor (NRTTI) Blocks key enzyme HIV needs to make copies of itself Delivering continued innovation leaving no person living with HIV behind gsk 78

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