Investor Presentation - First Six Months of 2021

104 Investor presentation First six months of 2021 Insulin market size and volume market share in Rest of World Insulin market share and market size (DKK billion) Total 56% Fast- 39% 4 acting Long- acting 61% 2 Premix 80% 2 Human 64% 2 Novo Nordisk Competitors Market growth A Market share 80% 11 -3% +0.4% 60% -1% +0.5% 40% 4% +0.5% Insulin volume: market share 20% -3% +1.0% 0% May 2018 -6% +0.6% -NN market share Source: IQVIA, May 2021, LHS graph - Value, RHS Graph - Volume, MAT;; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Market growth (right axis) NN growth (right axis) Rest of World 20% 57% 15% 10% 6% 5% 0% May 2021

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