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Investor Presentaiton

TWO SIGNIFICANT DISEASES Diabetic Macular Edema (DME) Q Chronic complication and leading cause of blindness in diabetic patients QU.S. diabetic population of 32 million in 2021 growing at ~11% per year Q Approximately 1.7 million patients in Alimera's major markets in 20201 Q Approximately 4.1% of all diabetics develop clinically significant macular edema alimera Non-Infectious Uveitis Affecting the Posterior Segment Q Chronic inflammatory conditions that can lead to pain, visual impairment and vision loss; often affects working age adults Q Over 500,000 patients in U.S. with non- infectious uveitis affecting the posterior segment² Between 40-50% of uveitis cases affect the posterior segment³ NOTES: 1. Data from IDF Atlas 10th Edition and Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045 Systematic Review and Meta-analysis 2021. Major markets include U.S., France, Germany, Italy, UK, Portugal, and Spain 2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904090/#:~:text=From%20the%205106%20interviewed %20US,20%20to%2069%20years%20 old and https://retinatoday.com/articles/2016-july-aug/the-burden-of-noninfectious-uveitis-of-the-posterior-segment-a-review 3. https://retinatoday.com/articles/2016-july-aug/the-burden-of-noninfectious-uveitis-of-the-posterior-segment-a-review Nasdaq: ALIM 6
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