Investor Presentaiton

☐ Protect Our Planet ▪ With more than 20,000 employees working across >150 locations in >20 countries, our commitment to operating our business responsibly and sustainably extends to the communities where we live and work ■ Committed to achieving 100% renewable electricity by end of 2030 utilizing vPPAs in North America (solar) and Europe (wind) Working in a healthy, safe, and sustainable manner is embedded in everything we do and every decision we make Employees are encouraged to actively engage as leaders in our sustainability initiatives ■ With our supply chain partners, we operate responsibly to ensure quality, accountability, and visibility across our value chain - Utilize tools that improve the completeness and accuracy of our supplier data and identify potential risk ■ As a member of the Pharmaceutical Supply Chain Initiative (PSCI) and Energize, we expect all our suppliers to act both responsibly and sustainably Working safely and sustainably 24% Decrease in Scope 1 and 2 GHG emissions on an absolute basis from 2018 to 2022 ~90% Renewable electricity achieved from virtual power purchase agreements (vPPAs) as of August 2023 (1) $3.7M Capital projects to reduce annual GHGs funded in 2022 under the CRL Sustainability Capital Fund Charles River Laboratories (CRL) (1) Represents a meaningful increase from YE 2022 figure of 37% renewable energy because U.S. and European vPPAs are now in effect. 9

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