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Investor Presentaiton

Research framework applied to Oncology builds on our scientific depth in immuno-oncology Strategy: Build a portfolio of foundational assets to address key tumor intrinsic and tumor extrinsic mechanisms, where combinations will be critical for durable responses with transformational potential. || || We have deep expertise in tumor extrinsic biology Immune Checkpoints Only company with three approved T cell checkpoint inhibitors (CPIs) Insights from translational datasets to guide the next-generation of transformational medicines Bristol Myers Squibb™ Tumor Extrinsic Adaptive and Innate Immunity Stroma Next-gen T cell CPIs Anti-CTLA4 next-gen, anti-TIGIT bi-specific, dual DGKα/ inhibitor Other immune cells Tregs anti-CCR8 Myeloid anti-ILT4 NK cells anti-NKG2A Aberrant Stromal Biology Neoantigens JNK inhibitor, TGFB inhibitor Not for Product Promotional Use 22
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