First Quarter 2017 Financial Review

Interest Rate Sensitivity Remain well positioned for rising rates Standard Model Assumptions Interest Rates 200 bps gradual, non-parallel rise Modest increase Loan Balances Deposit Balances Deposit Pricing (Beta) Securities Portfolio Loan Spreads MBS Prepayments Hedging (Swaps) Moderate decrease Historical price movements with short-term rates Held flat with prepayment reinvestment Held at current levels Third-party projections and historical experience No additions modeled Estimated Net Interest Income: Annual (12 month) Sensitivities Based on Various Assumptions Additional Scenarios are Relative to 1Q17 Standard Model ($ in millions) -90 ~240 -200 ~185 -185 150 -310 Up 100 Addl. $3B Addl. Addl. $1B Standard Addl. bps Deposit 20% Deposit Model -3% Loan Decline Increase Decline in Beta Up 300 bps Growth 3/31/17 For methodology see the Company's Form 10-K, as filed with the SEC. Estimates are based on simulation modeling analysis. Comerica Bank Ⓡ 19 Commercial Real Estate Line of Business Long history of working with well established, proven developers CRE by Property Type¹ ($ in millions; Period-end) CRE by Market¹ ($ in millions; Period-end, based on location of property) Office 7% Single Family Multi use Commercial 12% 7% 4% Land Carry 4% Other Austin 4% 7% Other 24% Houston 8% Retail 11% Other Total $4,583 6% Dallas 12% Total $4,583 Multifamily 49% Texas 31% California 45% CRE Period-end² ($ in billions) Criticized Loans³ ($ in millions) Criticized as a % of Total Loans Net Charge-offs (Recoveries) ($ in millions) 5.5 5.1 5.4 5.3 5.3 (11) (1) (2)0 99 84 73 46 49 1.9 1.5 1.4 0.9 0.9 1Q16 2Q16 3Q16 4Q16 1Q17 1Q16 2Q16 3Q16 4Q16 1Q17 1Q16 2Q16 3Q16 4Q16 1Q17 3/31/17 Excludes CRE line of business loans not secured by real estate ⚫2Includes CRE line of business loans not secured by real estate ⚫3Criticized loans are consistent with regulatory defined Special Mention, Substandard & Doubtful categories Comerica Bank 20

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