Investor Presentation Q1-Q3 2020

35 Investor presentation First nine months of 2020 Novo NordiskⓇ People with diabetes have increased mortality risk with eight years shorter life expectancy, highlighting the importance of innovation Diabetes is associated with shorter life expectancy and lower quality of life 463 • Life expectancy 8 years shorter¹ Diabetes • Driven by 200% increased risk of all cause mortality¹ The unmet need remains large within diabetes 101 Untreated (million) Treated with competitors' products (million) Treated with Novo Nordisk' products (million) CVD • 70% of people with diabetes die from atherosclerotic CVD² • 150% increase in risk of stroke³ • Higher likelihood of neuropathy, Organs retinopathy, limb amputation, cancer and cognitive dysfunction4 183 30 Diabetic population5 56 24 3 Other OAD Insulin Branded OAD GLP-1 1 Diabetes Care 2017 Mar; 40 (3): 338-345; 2 https://www.who.int/cardiovascular_diseases/en/; 3 https://www.diabetes.org/diabetes/complications/stroke.; CVD: Cardiovascular disease; OAD: Oral anti-diabetic; 4Diabetes Care2005 Jan;28(1):164-176 5 IDF diabetes world atlas, 2017, 8th edition

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