Investor Presentaiton

6 Dose-Related and Sustained Suppression of IGF1 in Beagle Dogs -5 -10 IGF1-% - Decrease from Pre-Treatment Levels -15 5 -2% -21.4% -20 -27.8% -25 ■AZP-3813 0.1mg/kg -30 AZP-3813 1.0mg/kg Means + SEM n=3 -35 ■AZP-3813 10mg/kg IGF-1 (ng/mL) A. 120 IGF-1 (ng/mL) B. 150 100 100 1 mg/kg AZP-3813 (repeated 5 days) 80 60 60 T T -3 0 1 T T T T T 2 3 4 5 6 7 8 Days 1 mg/kg (repeated - 4 days) 10 mg/kg (single) H 50 T T 1 2 3 Days AMOLYT PHARM A

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