Q4 2022 Results

Company overview Innovation: Pipeline overview Cardiovascular ligelizumab-IgE Inhibitor Financial review Immunology 2023 priorities Innovation: Clinical trials Neuroscience NCT04984876 (CQGE031G12301) Indication Phase Patients Primary Outcome Measures Arms Intervention Food allergy Phase 3 486 1. Proportion of participants who can tolerate a single dose of ≥ 600 mg (1044 mg cumulative tolerated dose) of peanut protein without dose-limiting symptoms at Week 12 Arm 1: ligelizumab 240 mg subcutaneous injection for 52 weeks Arm 2: ligelizumab 120 mg subcutaneous injection for 52 weeks Arm 3: Placebo subcutaneous injection for first 8 weeks and ligelizumab 120 mg subcutaneous injection for 44 weeks Arm 4: Placebo 16 weeks and ligelizumab 120 mg/240 mg subcutaneous injection for 36 weeks Arm 5: Placebo subcutaneous injection for first 8 weeks and ligelizumab 240 mg subcutaneous injection for 44 weeks Participants with a medically confirmed diagnosis of IgE-mediated peanut allergy Target Patients Readout Milestone(s) Publication 2025 TBD 73 Investor Relations | Q4 2022 Results Oncology Appendix Abbreviations Other NOVARTIS | Reimagining Medicine

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