First Quarter 2018 Investor Presentation

Investor Presentation First three months of 2018 Slide 39 The insulin market is comprised of three segments 6:00 10:00 ↑ Breakfast changing diabetes® Insulin action profiles tMU 500 Global insulin volume market by segment CAGR volume¹: 5.0% CAGR value¹: 16.4% Fast-acting 400 35% Fast-acting 34% 300 Premix 26% 200 Premix 29% Long-acting 100 40% 37% Long-acting 0 14:00 18:00 22:00 2:00 6:00 ↑ ↑ Time of day Feb 2013 Feb 2018 Lunch Dinner 1 CAGR for 5-year period. Value in DKK Source: IQVIA monthly MAT volume and value Feb 2018 (DKK) figures novo nordisk

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