Q3 2022 Results slide image

Q3 2022 Results

Company overview Financial review 2022 priorities Appendix References ZolgensmaⓇ sales now predominantly incident patient population C Ezolgensma K KL Sales evolution USD m Ex-US Both US and ex-US market now mainly incident patient population US 375 379 363 342 319 315 ◉ YTD double digit growth in incident patients treated 319 ◉ 2500+ patients treated worldwide¹ 254 249 256 224 250 200 209 220 ◉ 148 106 119 126 106 118 113 123 99 Q4 Q1 Q2 Q3 Q4 Q1 Q2 2020 2021 2022 1. Across clinical trials, managed access programs and in the commercial setting. 9 Investor Relations | Q3 2022 Results 3 Q3 Future growth drivers ☐ ☐ Foundational treatment for SMA type 1 newborns Now approved in 45 countries with access pathways in place in 30+ - Access negotiations ongoing in 10+ countries (e.g. Brazil, Argentina) Efforts ongoing to increase newborn screening (35% in Europe; 98% in US) IT data: STEER enrolling continues; STRENGTH to start in Q4 2022 NOVARTIS | Reimagining Medicine
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